Mechanistic investigation leads to a synthetic improvement in the hydrolytic kinetic resolution of terminal epoxides.
نویسندگان
چکیده
The mechanism of the hydrolytic kinetic resolution (HKR) of terminal epoxides was investigated by kinetic analysis using reaction calorimetry. The chiral (salen)Co-X complex (X = OAc, OTs, Cl) undergoes irreversible conversion to (salen)Co-OH during the course of the HKR and thus serves as both precatalyst and cocatalyst in a cooperative bimetallic catalytic mechanism. This insight led to the identification of more active catalysts for the HKR of synthetically useful terminal epoxides.
منابع مشابه
Mechanistic basis for high reactivity of (salen)Co-OTs in the hydrolytic kinetic resolution of terminal epoxides.
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ورودعنوان ژورنال:
- Journal of the American Chemical Society
دوره 126 5 شماره
صفحات -
تاریخ انتشار 2004